Cell cycle in myelodysplastic syndrome
نویسندگان
چکیده
منابع مشابه
Myeloid Cell Leukemia-1 Gene Expression and Clinicopathological Features in Myelodysplastic Syndrome
Background and Aims: Myeloid cell leukemia-1 (Mcl-1) plays a pivotal role in the survival of hematologic and solid tumors, and is known as a substantial oncogene. Studies have demonstrated the altered expression of Mcl-1 has been linked to malignancy development and poor prognosis. In this research, we have studied the expression of Mcl-1 mRNA in myelodysplastic syndrome (MDS) patients and det...
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Six cases of red cell aplasia occurring in patients with myelodysplastic syndromes (MDS) showed a diversity of clinical course and prognosis. In some patients red cell aplasia may have represented an evolution of MDS while in others autoimmune destruction of erythoblasts may have been the mechanism. A proliferative phase is seen in many of these patients, the clinical importance of which is unc...
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2. Hackel, D.B., Reimer, K.A., Ideker, R.E. et al. Comparison of enzymatic and anatomic estimates of myocardial infarct size in man. Circulation 1984, 70: 824-835. 3. Ogawa, H., Hiramori, K., Haze, K. et al. Comparison of clinical features of non-Q wave and Q wave myocardial infarction. Am Heart J 1986, 111: 513-518. 4. Wei, J.Y., Markis, J.E., Malagold, M. & Grossman, W. Time course of serum c...
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Allogeneic hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome, but patients with this disease are often older and frail, and treatment-related mortality and morbidity is a major obstacle to be overcome. Treatment of MDS is likely to benefit from the major lines of investigation in the field of allogeneic transplantation, especially intervention...
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Although high-dose chemotherapy may cure a small subset of patients with myelodysplastic syndrome (MDS), allogeneic hematopoietic cell transplantation (HCT) is the only currently available modality that is curative in a large proportion of patients. Approximately 30% to 40% of patients with high-risk MDS and 60% to 80% of patients with low-risk MDS survive long-term in remission. Disease classi...
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ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1994
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.106.7-8_861